The PROUD study, led by Dr. Sheena McCormack, was the first study to demonstrate that daily oral PrEP with FTC/TDF was highly effective among gay and bisexual men in the setting of existing sexual health clinics. Other trials had relied heavily on clinical trials units, while the PROUD study was based in existing clinics. The PROUD study was also more "real world" in that clients knew what they were getting - there was no placebo or blinding. The study was rigorous because clients were randomized to either start open label PrEP immediately or defer starting PrEP for a year. The level of protection achieved was enormous, so the safety monitoring board stopped the study.
Dr. McCormack has kindly provided documents that guide how PrEP is used in demonstration project that continues (see the Sources section). PrEP is not yet approved by the National Health Service in the UK, so there are no official documents. Yet these documents are valuable for setting up PrEP services in sexual health clinics.